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. 2013 Oct 9;54(10):6612–6619. doi: 10.1167/iovs.13-12861

Figure 4.

Figure 4

Graph of (A) the average construct thickness, (B) total number of cells per unit area (millimeter squared), and (C) the ratio of constructs' thickness over cell per unit area for both HCKs and HCFs stimulated with VitC ± T3. (A) Both HCK and HCF constructs' thicknesses were significantly upregulated (3- and 1.6-fold, respectively; P < 0.001) when stimulated with T3. HCFs total thickness was higher (2–4-fold) under all conditions when compared with HCKs. (B) HCFs had a higher number of cells per unit area ± T3 stimulation when compared with HCKs. A significant decrease in number of cells per unit area following T3 stimulation (P < 0.001) is shown for HCKs compared with VitC only. (C) The ratio of construct thickness/cells per unit area shows the difference in ECM secretion between HCKs and HCFs ± T3. The amount of ECM per cell was dramatically increased in HCKs upon T3 stimulation (∼11-fold) compared with that of the HCFs (∼3-fold), suggesting a greater ability of the HCKs to increase ECM production than HCFs.