Table 2.

Randomized Therapy and Development of Abnormal Thyroid Function

	Randomized Therapy
	Amiodarone	ICD	Placebo
Euthyroid at baseline	639	626	665
Hyperthyroid, new onset	8.0% (51)	2.4% (15)	3.5% (23)
Hypothyroid, new onset	32.9% (210)	9.9% (62)	10.4% (69)
Any abnormal thyroid function, new onset	40.9% (261)	12.3% (77)	13.8% (92)
Relative risk for new-onset abnormal thyroid function,  vs. placebo	3.65 (2.88–4.63) (p < 0.0001)	0.87 (0.65–1.18) (p = 0.38)	—
Relative risk for new-onset abnormal thyroid function,  vs. ICD	4.18 (3.24–5.39) (p < 0.0001)	—	—

Values are n, % (n), or hazard ratio (95% confidence interval).

CI = confidence interval; HR = hazard ratio; ICD = implantable cardioverter-defibrillator.