Table 2.

Association between miRNA SNPs and breast cancer in CBCS cases (invasive and CIS) and controls

		African Americans				Caucasians
Locus/SNP	Genotype	Cases (N)	Controls (N)	OR (95% CI)a	P-valuea,b	Cases (N)	Controls (N)	OR (95% CI)a	P-valuea,b
mir-9-1
rsl2239077	AA	707	631	Referent		1204	1087	Referent
	AG+GG	35	27	1.14 (0.67 – 1.95)	0.63	0	2	na	na
mir-9-2
rs 1501672	TT	481	415	Referent		914	841	Referent
	CT+CC	261	243	0.91 (0.72 – 1.14)	0.39	290	248	1.05 (0.86 – 1.30)	0.61
mir-16-1/15a
rs9535416	GG	445	397	Referent		281	259	Referent
	AG+AA	297	261	1.03 (0.83 – 1.29)	0.78	923	830	1.02 (0.83 – 1.26)	0.82
mir-34b/34c
rs4938723	TT	362	343	Referent		496	430	Referent
	TC	317	257	1.16 (0.92 – 1.46)	0.21	563	503	0.93 (0.77 – 1.12)	0.46
	CC	63	58	1.08 (0.73 – 1.61)	0.69	144	155	0.80 (0.60 – 1.05)	0.10
mir-185
rs2008591	CC	204	170	Referent		424	390	Referent
	CT	383	306	1.11 (0.86 – 1.45)	0.42	586	527	1.01 (0.84 – 1.23)	0.90
	TT	155	182	0.72 (0.53 – 0.98)	0.04	193	172	1.05 (0.81 – 1.37)	0.71
rs887205	AA	173	132	Referent		397	365	Referent
	AG	360	304	0.92 (0.69 – 1.21)	0.54	595	533	1.02 (0.84 – 1.24)	0.85
	GG	208	222	0.71 (0.52 – 0.96)	0.03	210	191	1.02 (0.79 – 1.32)	0.87
rs2078749	AA	447	412	Referent		299	270	Referent
	AG+GG	294	246	1.08 (0.86 – 1.35)	0.50	904	819	1.00 (0.82 – 1.23)	0.97
mir-206
rs6920648	AA	342	282	Referent		370	325	Referent
	AG	308	296	0.84 (0.66 – 1.05)	0.13	564	554	0.85 (0.70 – 1.04)	0.11
	GG	91	80	0.97 (0.69 – 1.38)	0.88	269	209	1.15 (0.90 – 1.47)	0.28
rsl6882131	CC	365	342	Referent		671	592	Referent
	CT	308	254	1.15 (0.92 – 1.45)	0.22	458	419	0.94 (0.79 – 1.13)	0.53
	TT	69	62	1.00 (0.67 – 1.47)	0.98	75	78	0.82 (0.58 – 1.18)	0.29

^aP-values and ORs adjusted for age, ancestry and offset term is for general or dominant model (in the case of small sample size for rare homozygote). The offset term is included in the model using the OFFSET option in SAS Proc Logistic.

^bP-value is unadjusted for multiple comparisons