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Factors hypothesized to be involved in the increase/decrease of Aβ in HIV-infected brain (further work is needed).
| Aβ increase | Aβ decrease | |
|---|---|---|
| HIV-1, HIV-1 proteins | BBB transporters (LRP1, P-gp, MRP1, BCRP) | |
| Neuroinflammation | Statins | |
| Antiretroviral therapy | Lipid raft/caveolae disruption | |
| BBB transporters: RAGE | Ras/MAPK inhibition | |
| Agrin | ||
| Peripheral sink effect -Aβ transporters (sLRP1, sRAGE) | ||
| -Aβ degrading enzymes (Neprilysin) | ||
