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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Neuron. 2013 Jul 24;79(2):335–346. doi: 10.1016/j.neuron.2013.05.016

Fig 3. Normal inhibitory input onto pyramidal cell but reduced excitatory input onto FS (PV) INs in NARP−/− mice.

Fig 3

A–C. Extracellularly-evoked IPSCs (eIPSCs) recorded in pyramidal neurons are normal in P35 NARP−/− mice. A. Pharmacologically-isolated eIPSCs were recorded in layer II/III pyramidal neurons, evoked by extracellular stimulation of the underlying layer IV. B. Input-output relationship for eIPSCs in NARP−/− (red) and WT controls (black). C. Maximal IPSC computed by averaging eIPSC amplitudes evoked by the 3 largest stimulus intensities. D–F. Extracellularly- evoked EPSCs (eEPSCs) recorded in FS (PV) INs are reduced in P35 NARP−/− mice. D. Pharmacologically-isolated eEPSCs were recorded in layer II/III FS (PV) INs, evoked by extracellular stimulation of the underlying layer IV. E. Input-output relationship for eEPSCs in NARP−/− (red) and WT controls (black). F. Maximal EPSC computed by averaging eEPSC amplitudes evoked by the 3 largest stimulus intensities. Number of mice and neurons in parentheses in B and E. *=p<0.02; t-test.