Table 1.
Quantitative summary of MT-stabilizing trends for MAP4 in the presence and absence of Taxol.
Interface | Total ΔHDX (α) | P | Total ΔHDX (β) | P | ||
---|---|---|---|---|---|---|
MAP4 | MAP4+Taxol | MAP4 | MAP4+Taxol | |||
Interdimer | −136 ± 38 | −118 ± 40 | 0.6 | −270 ± 18 | −246 ± 18 | 0.1 |
Intradimer | −108 ± 43 | −292 ± 54 | 0.003 | −184 ± 24 | −441 ± 36 | 0.000 |
Lateral | −142 ± 15 | −17 ±21 | 0.001 | −81 ± 41 | −298 ± 43 | 0.001 |
Peptide α154-166 was not included in the total ΔHDX calculation at the interdimer interface for reasons referred to in the “Results” section.