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. Author manuscript; available in PMC: 2013 Oct 21.
Published in final edited form as: ACS Chem Biol. 2012 Feb 6;7(4):744–752. doi: 10.1021/cb200403x

Table 1.

Quantitative summary of MT-stabilizing trends for MAP4 in the presence and absence of Taxol.

Interface Total ΔHDX (α) P Total ΔHDX (β) P
MAP4 MAP4+Taxol MAP4 MAP4+Taxol
Interdimer −136 ± 38 −118 ± 40 0.6 −270 ± 18 −246 ± 18 0.1
Intradimer −108 ± 43 −292 ± 54 0.003 −184 ± 24 −441 ± 36 0.000
Lateral −142 ± 15 −17 ±21 0.001 −81 ± 41 −298 ± 43 0.001
*

Peptide α154-166 was not included in the total ΔHDX calculation at the interdimer interface for reasons referred to in the “Results” section.