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In vitro studies of NPs incubated with human β2 microglobulin resulting in protein corona formation on particles (Linse et al., 2007). This nanoparticle-protein association led to nucleation and acceleration of protein fibrillation (unfolding) by the nanoparticles. (shown here for Co-polymer NP; was also observed by the authors with QDs, Ceria, CNTs).
