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. Author manuscript; available in PMC: 2013 Oct 21.
Published in final edited form as: Epilepsy Behav. 2012 May 30;24(3):10.1016/j.yebeh.2012.04.120. doi: 10.1016/j.yebeh.2012.04.120

Table 1.

Behavioral responses to TPM, LZP, and PLA, relative to a no-treatment baseline, as captured by neuropsychological and speech measures.

Change score of TPM*
from baseline		 Change score of LZP** from
baseline		 Change score of PLA from
baseline
Predicted
group
mean
(SE)		 Test of
change
from
baseline
p value		 Predicted
group
mean
(SE)		 Test of
change
from
baseline
p value		 Test of
LZP vs.
TPM
p value		 Predicted
group
mean
(SE)		 Test of
change
from
baseline
p value		 Test of
PLA
vs.
TPM
p value
Gen. Verbal Fluency
  Phonemic (FAS/BHR) −0.24 (0.04) <0.0001 −0.05 (0.05) 0.35 0.0031 −0.003 (0.04) 0.94 <0.0001
  Category
    Animals/Clothing −0.09 (0.06) 0.10 0.13 (0.07) 0.10 0.05 −0.01 (0.06) 0.83 0.47
    Boy/Girl names −0.24 (0.06) 0.0002 0.05 (0.07) 0.43 0.0006 −0.02 (0.06) 0.79 0.0009
    Switching −0.20 (0.05) 0.0002 0.02 (0.07) 0.80 0.04 0.002 (0.05) 0.97 0.01
MCG IR 1
  Word Count −0.14 (0.08) 0.09 −0.21 (0.12) 0.08 0.88 0.08 (0.08) 0.36 0.16
  Correct Words −0.21 (0.10) 0.04 −0.23 (0.14) 0.11 0.99 0.24 (0.10) 0.02 0.007
  Disfluency rate 0.11 (0.17) 0.55 −0.56 (0.22) 0.01 0.01 −0.09 (0.18) 0.63 0.48
MCG IR 2
  Word Count −0.19 (0.06) 0.003 −0.15 (0.08) 0.06 0.90 0.13 (0.06) 0.08 0.0003
  Correct Words −0.10 (0.07) 0.16 −0.30 (0.10) 0.007 0.29 0.33 (0.07) 0.0001 0.001
  Disfluency rate 0.04 (0.12) 0.74 −0.35 (0.17) 0.04 0.12 −0.19 (0.12) 0.13 0.29
MCG Delayed Recall
  Word Count −0.08 (0.07) 0.30 −0.18 (0.10) 0.09 0.69 0.12 (0.07) 0.11 0.13
  Correct Words −0.09 (0.08) 0.28 −0.27 (0.12) 0.04 0.49 0.37 (0.08) 0.0001 0.001
  Disfluency rate 0.32 (0.26) 0.22 −0.15 (0.30) 0.61 0.11 0.11 (0.26) 0.68 0.44
Picture Descript-Standard
  Word Count 0.14 (0.08) 0.11 0.10 (0.12) 0.39 0.96 0.17 (0.09) 0.07 0.98
  Correct Information Units 0.27 (0.09) 0.004 0.15 (0.11) 0.19 0.52 0.25 (0.09) 0.008 0.97
  Disfluency rate 0.66 (0.24) 0.01 0.14 (0.26) 0.59 0.009 0.16 (0.24) 0.51 0.002
Picture Descript-MAPDS
  Word Count 0.002 (0.11) 0.99 0.19 (0.13) 0.14 0.20 0.19 (0.11) 0.09 0.08
  Correct Information Units −0.02 (0.09) 0.81 −0.02 (0.13) 0.85 1.00 0.19 (0.10) 0.07 0.14
  Disfluency rate 1.12 (0.83) 0.19 0.80 (0.84) 0.35 0.12 0.89 (0.83) 0.29 0.15

TPM, topiramate; LZP, lorazepam; PLA, placebo

IR1, immediate recall 1; IR2, immediate recall 2

*

N= 20

**

LZP was only administered to UMN participants only (N=11)