Table 2.

Top 20 Hits From LOPAC Screen Described in Figure 6

Compound name	Cat no.	Sigma class	Description
Salmeterol xinafoate	S 5068	Adrenoceptor	Beta2 adrenoceptor agonist
GW1929	G 5668	Transcription	PPAR-gamma agonist
(−)-Alpha-methylnorepinephrine	D 5290	Adrenoceptor	Adrenoceptor agonist; vasoconstrictor; antihypertensive
cis-(Z)-Flupenthixol dihydrochloride	F-114	Dopamine	Dopamine receptor antagonist; antipsychotic
HE-NECA	H 8034	Adenosine	A2 adenosine receptor agonist
Felodipine	F 9677	Ca2+ channel	L-type calcium channel blocker
(−)-Isoproterenol hydrochloride	I 6504	Adrenoceptor	Beta-adrenoceptor agonist; increases cytosolic cAMP
N-phenylanthranilic acid	144509	Cl− channel	Cl− channel blocker
R(−)-N6(2-phenylisopropyl)adenosine	P 4532	Adenosine	A1 adenosine receptor agonist
5′-N-ethylcarboxamidoadenosine	E 2387	Adenosine	Adenosine A1 and A2 receptor agonist
R(−)-isoproterenol (+)-bitartrate	I 2760	Adrenoceptor	Agonist at beta adrenoceptors; bronchodilator.
Ritodrine hydrochloride	R 0758	Adrenoceptor	Beta2-adrenoceptor agonist; relaxes uterine muscle contractions
Formoterol	F 9552	Adrenoceptor	Beta2-adrenoceptor agonist
Isotharine mesylate	I 3639	Adrenoceptor	Beta-adrenoceptor agonist; bronchodilator
(±)-6-Chloro-PB hydrobromide	S-143	Dopamine	D1 dopamine receptor agonist
2-Chloroadenosine triphosphate tetrasodium	C-145	P2 receptor	P2Y receptor agonist
5′-(N-cyclopropyl)carboxamidoadenosine	C 6042	Adenosine	Potent A2 adenosine receptor agonist
Dihydrexidine hydrochloride	D 5814	Dopamine	D1 dopamine receptor agonist
5′-N-methyl carboxamidoadenosine	A-024	Adenosine	Adenosine receptor agonist with selectivity for A2 over A1
Fenoterol hydrobromide	F 1016	Adrenoceptor	Beta2-adrenoceptor agonist; bronchodilator

LOPAC, Library of Pharmacologically Active Compounds; PPAR, peroxisome proliferator activated receptor.