Table 2.
List of the Genes in Most Significantly Upregulated Canonical Pathways Associated with Runx2 and Twist2
| Category | Functions annotation | P-value | Molecules |
|---|---|---|---|
| Skeletal and muscular system development and function | Differentiation of osteoblasts | 2.03E-04 | BGN, DKK1, GREM1, RUNX2, TWIST2 |
| Cellular growth and proliferation | Proliferation of cells | 4.95E-04 | AKR1C1/AKR1C2, AKR1C3, ALDH1A1, ALDH1A2, BGN, CAMK2N1, COMP, DKK1, GREM1, IBSP, MAFB, RUNX2, SOX9, TBX3, TWIST2, WNT2, ZNF423 |
| Cellular development | Differentiation of cells | 1.36E-03 | AKR1C3, ALDH1A2, BGN, DKK1, EBF2, GREM1, IBSP, MAFB, RUNX2, SOX9, TBX3, TWIST2 |
| Cellular development | Differentiation of connective tissue cells | 2.16E-03 | BGN, DKK1, GREM1, RUNX2, SOX9, TWIST2 |
| Cell death and survival | Cell death | 5.15E-03 | ADAMTS12, ALDH1A1, ALDH1A2, BGN, COMP, DKK1, GREM1, IBSP, MAFB, RUNX2, SOX9, TBX3, TWIST2, WNT2, ZNF423 |
| Gene expression | Transcription of DNA | 6.21E-03 | DKK1, EBF2, GREM1, MAFB, RUNX2, SOX9, TBX3, TWIST2, ZNF423 |
| Cell death and survival | Apoptosis | 9.06E-03 | ALDH1A1, ALDH1A2, BGN, COMP, DKK1, GREM1, MAFB, RUNX2, SOX9, TBX3, TWIST2, WNT2, ZNF423 |
Pathways were expressed at statistically significant different levels in bmMSC versus pMSC data sets (P<0.05) and are listed based on gene array data analyzed by Ingenuity Pathway Analysis. Six pathways annotated to categories cancer and reproductive systems disease were omitted.