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. Author manuscript; available in PMC: 2014 Aug 8.
Published in final edited form as: J Med Chem. 2013 Jul 18;56(15):6216–6233. doi: 10.1021/jm400664x

Scheme 3a.

Scheme 3a

aReagents and conditions:

(a) CH3I, NaH, THF, rt, 0.5 h; (b) (CH3CO)2O, Et3N, CH2Cl2, rt; (c) Concentrated HCl, ethylene glycol, refluxed; d) Separation of enantiomers of 24b on HPLC: column: Chiralcel OD; mobile phase: 35% isopropanol in hexane; flow rate: 4.0 mL/min; (+)-enantiomer at 15 min and (-)-enantiomer at 30 min;