Table 1.
Mutation Positive | Mutation Negative | P-value | |
---|---|---|---|
Probands | 113 (49%) | 117 (51%) | |
UCSF (%) | 71 (56%) | 55 (44%) | |
UC (%) | 42 (41%) | 62 (59%) | |
Women (%) | 73 (64%) | 77 (65%) | 0.89 |
Ethnicity | |||
Caucasian (%) | 88 (46%) | 102 (54%) | 0.08 |
African American (%) | 9 (60%) | 6 (40%) | 0.43 |
Other (%)* | 17 (65%) | 9 (35%) | 0.09 |
CRC (% probands affected) | 78 (69%) | 67 (57%) | 0.07 |
Mean age CRC (range in years) | 43 (21–72) | 50 (19–76) | 0.0001 |
EC (% probands affected) | 27 (23%) | 15 (12%) | 0.03 |
Mean age EC (range in years) | 45 (29–60) | 51 (32–88) | 0.16 |
Other Lynch tumor (% probands affected) | 17 (15%) | 12 (10%) | 0.32 |
hMLH1 | 47 (42%) | ||
hMSH2 | 51 (45%) | ||
hMSH6 | 15 (13%) | ||
1st degree relatives | |||
CRC (% FDR affected**) | 32% | 17% | 0.0001 |
Mean age CRC (years) | 47 | 53 | 0.001 |
EC (% FDR affected) | 13% | 4% | 0.0002 |
Other Lynch tumor (% FDR affected) | 9% | 6% | 0.07 |
2nd degree relative | |||
CRC (% SDR affected**) | 18% | 8% | 0.0001 |
Mean age CRC (years) | 46 | 61 | 0.0001 |
EC (% SDR affected) | 8% | 4% | 0.06 |
Other Lynch tumor (% SDR affected) | 5% | 3% | 0.16 |
UCSF, University of California San Francisco; UC, University of Chicago; CRC, colorectal cancer; EC, endometrial cancer
Other includes 10 Hispanic and 16 Asian individuals
%FDR and %SDR is a measure of number of FDR or SDR affected family members divided by total FDR or SDR family members at risk to account for family size