Table 2.

Quantitative Prediction Model Testing Characteristics at Sensitivities of 90%, 95% and 98%

	MMRPredict	PREMM(1,2,6)	MMRPro
>90% Sensitivity
Specificity	29%	38%	36%
LR+	1.3	1.4	1.4
Risk score cutoff*	>4%	>6%	>7%
>95% Sensitivity
Specificity	21%	0%	9%
LR +	1.2	1.0	1.0
Risk score cutoff	>2%	>0%	>1%
>98% Sensitivity
Specificity	10%	0%	0%
LR +	1.1	1.0	1.0
Risk score cutoff	>1%	>0%	>0%

LR+, positive likelihood ratio

^*MMRPredict & PREMM(1,2,6) output is expressed as predicted percentage risk of MMR mutation, while MMRPro as numerical probability of MMR mutation; for purposes of this table, all risk scores are shown as percentages