Table 2.
MMRPredict | PREMM(1,2,6) | MMRPro | |
---|---|---|---|
>90% Sensitivity | |||
Specificity | 29% | 38% | 36% |
LR+ | 1.3 | 1.4 | 1.4 |
Risk score cutoff* | >4% | >6% | >7% |
>95% Sensitivity | |||
Specificity | 21% | 0% | 9% |
LR + | 1.2 | 1.0 | 1.0 |
Risk score cutoff | >2% | >0% | >1% |
>98% Sensitivity | |||
Specificity | 10% | 0% | 0% |
LR + | 1.1 | 1.0 | 1.0 |
Risk score cutoff | >1% | >0% | >0% |
LR+, positive likelihood ratio
MMRPredict & PREMM(1,2,6) output is expressed as predicted percentage risk of MMR mutation, while MMRPro as numerical probability of MMR mutation; for purposes of this table, all risk scores are shown as percentages