Table 3.
MMRPredict | PREMM(1,2,6) | MMRPRO | ||
---|---|---|---|---|
N= | 4 pts | 5 pts | 6 pts | |
Proband | ||||
Women | 4/4 | 4/5 | 3/6 | |
CRC | 4/4 | 3/5 | 4/6 | |
Mean age CRC (years) | 49 | 44 | 34 | |
EC | 2/4 | 0/5 | 0/6 | |
Mean age EC (years) | 48 | NA | NA | |
Other Lynch tumor | 1/4 | 1/5 | 2/6 | |
hMLH1 | 2/4 | 1/5 | 3/6 | |
hMSH2 | 1/4 | 4/5 | 3/6 | |
hMSH6 | 1/4 | 0/5 | 0/6 | |
1st degree relatives | ||||
CRC (% FDR affected) | 21% | 25% | 18% | |
Mean age CRC (years) | 50 | 55 | 69 | |
EC (% FDR affected) | 0% | 0% | 0% | |
Other Lynch tumor (% FDR affected) | 7% | 4% | 15% | |
2nd degree relative | ||||
CRC (% SDR affected) | 8% | 29% | 1% | |
Mean age CRC (years) | 48 | 73 | 45 | |
EC (% SDR affected) | 0% | 20% | 0% | |
Other Lynch tumor (% SDR affected) | 8% | 10% | 5% |
CRC, colorectal cancer; EC, endometrial cancer; FDR, first degree relative;