. Author manuscript; available in PMC: 2013 Oct 21.

Published in final edited form as: Am J Gastroenterol. 2011 Jul 12;106(10):1822–1828. doi: 10.1038/ajg.2011.200

Table 3.

Characteristics of mutation carriers missed exclusively by each predictive models

		MMRPredict	PREMM(1,2,6)	MMRPRO

	N=	4 pts	5 pts	6 pts
Proband
Women		4/4	4/5	3/6
CRC		4/4	3/5	4/6
Mean age CRC (years)		49	44	34
EC		2/4	0/5	0/6
Mean age EC (years)		48	NA	NA
Other Lynch tumor		1/4	1/5	2/6
hMLH1		2/4	1/5	3/6
hMSH2		1/4	4/5	3/6
hMSH6		1/4	0/5	0/6
1^st degree relatives
CRC (% FDR affected)		21%	25%	18%
Mean age CRC (years)		50	55	69
EC (% FDR affected)		0%	0%	0%
Other Lynch tumor (% FDR affected)		7%	4%	15%
2^nd degree relative
CRC (% SDR affected)		8%	29%	1%
Mean age CRC (years)		48	73	45
EC (% SDR affected)		0%	20%	0%
Other Lynch tumor (% SDR affected)		8%	10%	5%

CRC, colorectal cancer; EC, endometrial cancer; FDR, first degree relative;