Table 3. Transferability to AfAs of FG- and FI-related loci previously reported in EuA populations.

Nearest gene(s)	Index SNP	Chr.	Position	Allelesb	EuA association			AfA association for index SNP				Heterogeneitya
					EAF	Effect ([mmol/l] per effect allele)	95% CI	EAF	Effect ([mmol/l] per effect allele)	95% CI	p value	p value
FG-associated loci
PROX1	rs340874	1	212225879	C/T	0.520	0.013	0.007, 0.019	0.169	0.006	−0.020, 0.031	6.63 × 10-1	6.00 × 10 1
G6PC2	rs560887	2	169471394	C/T	0.700	0.075	0.069, 0.081	0.943	0.060	0.019, 0.1000	4.08 × 10-3	4.80 × 10-1
GCKR	rs780094	2	27594741	C/T	0.620	0.029	0.023, 0.035	0.817	0.022	−0.002, 0.046	7.05 × 10-2	5.72 × 10-1
ADCY5	rs11708067	3	124548468	A/G	0.780	0.027	0.021, 0.033	0.843	0.015	−0.010, 0.041	2.31 × 10-1	3.68 × 10-1
SLC2A2	rs11920090	3	172200215	T/A	0.870	0.020	0.012, 0.028	0.645	0.005	−0.014, 0.025	5.81 × 10-1	1.64 × 10-1
GCK	rs4607517	7	44202193	A/G	0.160	0.062	0.054, 0.070	0.101	0.084	0.050, 0.118	1.42 × 10-6	2.088 × 10-1
DGKB-TMEM195	rs2191349	7	15030834	T/G	0.520	0.030	0.024, 0.036	0.593	0.016	−0.003, 0.036	1.02 × 10-1	1.80 × 10-1
SLC30A8	rs13266634	8	118253964	C/T	0.680	0.027	0.019, 0.035	0.908	0.004	−0.030, 0.038	8.16 × 10-1	1.88 × 10-1
GLIS3	rs7034200	9	4279050	A/C	0.490	0.018	0.012, 0.024	0.630	0.018	−0.001, 0.037	6.15 × 10-2	1.00 × 10-0
ADRA2A	rs10885122	10	113032083	G/T	0.870	0.022	0.014, 0.030	0.334	0.006	−0.014, 0.026	5.68 × 10-1	1.37 × 10-1
TCF7L2	rs7903146	10	114748339	T/C	0.290	0.023	0.015, 0.031	0.284	0.013	−0.010, 0.035	2.63 × 10-1	3.93 × 10-1
MTNR1B	rs10830963	11	92348358	G/C	0.300	0.067	0.061, 0.073	0.073	0.104	0.069, 0.139	8.51 × 10-9	4.26 × 10-2
MADD	rs7944584	11	47292896	A/T	0.750	0.021	0.015, 0.027	0.950	0.017	−0.024, 0.059	4.18 × 10-1	8.50 × 10-1
FADS1	rs174550	11	61328054	T/C	0.640	0.017	0.011, 0.023	0.916	0.014	−0.019, 0.048	3.99×10-1	8.62×10-1
CRY2	rs11605924	11	45829667	A/C	0.490	0.015	0.009, 0.021	0.867	0.016	−0.012, 0.043	2.71×10 1	9.44×10 1
C2CD4B	rs11071657	15	60221254	A/G	0.630	0.008	0.002, 0.014	0.868	0.006	−0.027, 0.038	7.37×10-1	9.08×10-1
FI-associated loci
GCKR	rs780094	2	27594741	C/T	0.620	0.032	0.024, 0.040	0.817	0.025	−0.00, 0.053	7.67 ×10-2	6.31×10-1
IGF1	rs35767	12	101399699	G/A	0.850	0.010	−0.002, 0.022	0.570	0.001	−0.022, 0.023	9.49×10-1	5.02×10-1

The loci in this table were all obtained from Dupuis et al (2010) [8]

^aHeterogeneity test of the β coefficients for EuA populations and AfAs

^bEffect (trait-raising)/other allele

Chr chromosome; EAF effect allele frequency