Table 5. Association with FG in AfAs of FG-associated type 2 diabetes risk SNPs previously reported in EuA populations.
| Nearest gene(s) | Index SNPd | Chr. | Position | Allelesb | EuA FG result for index SNP | AfA FG result for index SNP | Heterogeneitya | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
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| EAF | Effect ([mmol/l] per effect allele) | 95% CI | p value | EAF | Effect ([mmol/l] per effect allele) | 95% CI | p value | p value | |||||
| THADA | rs7578597 | 2 | 43586327 | C/T | 0.9 | 0.026 | 0.014, 0.037 | 2.40×10-5 | 0.72 | −0.003 | −0.023, 0.017 | 7.81×10-1 | 1.29×10-2 |
| ADAMTS9 | rs4607103 | 3 | 64686944 | T/C | 0.76 | −0.010 | −0.018, −0.001 | 2.64×10-2 | 0.71 | 0.028 | 0.008, 0.048 | 6.85×10-3 | 4.18×10-4 |
| IGF2BP2 | rs4402960 | 3 | 18699438 1 | T/G | 0.29 | 0.011 | 0.003, 0.018 | 8.34×10-3 | 0.51 | −0.003 | −0.021, 0.015 | 7.63×10-1 | 1.55×10-1 |
| ZBED3 | rs4457053 | 5 | 76460705 | G/A | 0.26 | 0.018 | 0.009, 0.026 | 9.15×10-5 | N/A | N/A | N/A | N/A | N/A |
| CDKAL1 | rs7754840 | 6 | 20769229 | C/G | 0.31 | 0.010 | 0.002, 0.017 | 1.41×10-2 | 0.57 | 0.008 | −0.010, 0.027 | 3.74×10-1 | 8.39×10-1 |
| TP53INP1 | rs896854 | 8 | 96029687 | T/C | 0.48 | 0.012 | 0.005, 0.019 | 8.79×10-4 | 0.69 | 0.022 | 0.002, 0.042 | 3.40×10-2 | 3.53×10-1 |
| SLC30A8 | rs1326663 4 | 8 | 11825396 4 | C/T | 0.75 | 0.027 | 0.018, 0.036 | 5.46×10-10 | 0.91 | 0.004 | −0.030, 0.038 | 8.16×10-1 | 1.88×10-1 |
| CDKN2A/B | rs1081166 1 | 9 | 22124094 | T/C | 0.79 | 0.019 | 0.009, 0.028 | 9.99×10-5 | 0.93 | 0.026 | −0.011, 0.063 | 1.68×10-1 | 7.22×10-1 |
| CDC123/CAMK1 D | rs1277979 0 | 10 | 12368016 | A/G | 0.18 | −0.016 | −0.025, −0.006 | 1.20×10-3 | 0.87 | −0.014 | −0.044, 0.015 | 3.40×10-1 | 8.99×10-1 |
| HHEX | rs1111875 | 10 | 94452862 | C/T | 0.56 | 0.009 | 0.002, 0.016 | 1.41×10-2 | 0.77 | −0.017 | −0.039, 0.004 | 1.16×10-1 | 2.63×10-2 |
| KCNQ1 | rs231362 | 11 | 2648047 | G/A | 0.52 | 0.019 | 0.011, 0.027 | 5.29×10-6 | 0.78 | −0.019 | −0.044, 0.006 | 1.46×10-1 | 5.21×10-3 |
| CENTD2c | rs1552224 | 11 | 72110746 | A/C | 0.88 | 0.019 | 0.010, 0.029 | 1.20×10-4 | 0.97 | −0.005 | −0.065, 0.055 | 8.73×10-1 | 4.45×10-1 |
| MTNR1B | rs1387153 | 11 | 92313476 | T/C | 0.28 | 0.060 | 0.052, 0.069 | 6.59×10-45 | 0.38 | 0.008 | −0.012, 0.028 | 4.38×10-1 | 1.38×10-6 |
| PRC1 | rs8042680 | 15 | 89322341 | A/C | 0.22 | 0.010 | 0.002, 0.017 | 1.30×10-2 | 0.84 | 0.019 | −0.007, 0.045 | 1.50×10-1 | 5.08×10-1 |
a
Heterogeneity test of the β coefficients for EuA populations and AfAs
b
Effect/other allele
c
Also known as ARAP1
d
Voight et al (2010) [7]; Zeggini et al (2008) [32]; Rung et al (2009) [53]; Altshuler (2000) [54]; Zeggini et al (2007) [33]; Scott et al (2007) [34], Diabetes Genetics Initiative of Broad Institute et al (2007) [55]; Sladek (2007) [36]; Gloyn (2003) [56]; Winckler et al (2007) [37]; Gudmundsson (2007) [58]
Chr., chromosome; N/A, not available