Study design for randomized controlled and open-label extension trials. DB, double blind; OLE, open-label extension; RCT, randomized controlled trial. aDose titration: 20 mg/day start (night), increased by 20 mg every 2 days to target dose. bFlexible dose: Ziprasidone 40–80 mg/day (<45 kg), ziprasidone 120–160 mg/day (≥45 kg).