Table 5.
|
RCT |
OLE |
||||
---|---|---|---|---|---|---|
Mean (SD) | n | Ziprasidone | n | Placebo | n | Ziprasidone |
SARS total score | ||||||
Baseline | 189 | 0.7 (2.1) | 87 | 0.6 (1.7) | 221 | 0.9 (2.2) |
Change from baseline to week 6− or week 26−LOCF | 189 | 0.3 (2.5) | 86 | −0.1 (0.6) | 206 | −0.2 (1.5) |
BARS | ||||||
Baseline | 190 | 0.1 (0.5) | 88 | 0.1 (0.3) | 221 | 0.1 (0.4) |
Change from baseline to week 6− or week 26−LOCF | 190 | 0.0 (0.6) | 87 | 0.0 (0.2) | 206 | 0.1 (0.5) |
AIMS | ||||||
Baseline | 190 | 0.2 (0.8) | 88 | 0.3 (0.9) | 221 | 0.3 (1.2) |
Change from baseline to week 6− or week 26−LOCF | 190 | 0.0 (0.8) | 87 | 0.0 (0.7) | 206 | 0.0 (1.0) |
RCT, randomized controlled trial; OLE, open-label extension; LOCF, last observation carried forward; BARS, Barnes Akathisia Rating Scale; AIMS, Abnormal Involuntary Movement Scale; SARS, Simpson-Angus Rating Scale.