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. 2013 Oct;16(5):364–376. doi: 10.1089/rej.2013.1439

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 3. — The effects of SiMaioFang (SMF) on aggrecanases-1 and -2 (ADAMTS-4 and -5), matrix metalloproteinases-3 and -13 (MMP-3 and -13), and tissue inhibitors of metalloproteinases-1 and -3 (TIMP-1 and -3) in the knee joints. (A) The effects of SMF on expression of ADAMTS-4 and -5 in the knee joints. (B) The effects of SMF on expression of MMP-3 and -13 and TIMP-1 and -3 in the knee joints. These enzymes expressions were assessed by quantitative immunohistochemistry. Photomicrographs taken at 200×magnification of representative cartilage sections from one animal per group are shown: Sham (i), anterior cruciate ligament transection+medial meniscus resection ACLT+MMx (ii), ACLT+MMx+SMF at 2.50 grams/kg (iii), ACLT+MMx+glucosamine 0.16 gram/kg (iv). Quantitative immunohistochemistry analyses of the expression of these enzymes in the tibia are shown, and data represent the mean±standard deviation (SD) of samples from 10 rats in each group. Comparing treatment group with untreated ACLT+MMx rats. (***) p<0.001, (**) p<0.01, and (*) p<0.05, compared with ACLT+MMx; (###) p<0.001, (##) p<0.01, and (#) p<0.05, compared with the sham group. (Color images available online at www.liebertpub.com/rej)

FIG. 3. — The effects of SiMaioFang (SMF) on aggrecanases-1 and -2 (ADAMTS-4 and -5), matrix metalloproteinases-3 and -13 (MMP-3 and -13), and tissue inhibitors of metalloproteinases-1 and -3 (TIMP-1 and -3) in the knee joints. (A) The effects of SMF on expression of ADAMTS-4 and -5 in the knee joints. (B) The effects of SMF on expression of MMP-3 and -13 and TIMP-1 and -3 in the knee joints. These enzymes expressions were assessed by quantitative immunohistochemistry. Photomicrographs taken at 200×magnification of representative cartilage sections from one animal per group are shown: Sham (i), anterior cruciate ligament transection+medial meniscus resection ACLT+MMx (ii), ACLT+MMx+SMF at 2.50 grams/kg (iii), ACLT+MMx+glucosamine 0.16 gram/kg (iv). Quantitative immunohistochemistry analyses of the expression of these enzymes in the tibia are shown, and data represent the mean±standard deviation (SD) of samples from 10 rats in each group. Comparing treatment group with untreated ACLT+MMx rats. (***) p<0.001, (**) p<0.01, and (*) p<0.05, compared with ACLT+MMx; (###) p<0.001, (##) p<0.01, and (#) p<0.05, compared with the sham group. (Color images available online at www.liebertpub.com/rej)