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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Expert Rev Mol Diagn. 2013 Mar;13(2):151–165. doi: 10.1586/erm.13.4

Figure 4. Integrative flow chart for discovery of knowledge to personalize DCIS treatment therapy.

Figure 4

The DCIS samples for NGS may come from experimental models or clinical samples (FFPE or fresh biopsy). Genes with similar expression patterns could be identified by RNA-Seq and the common promoter frameworks verified by ChIP-Seq. Combining systems bionetwork modeling approaches with clinicopathological characteristics, molecular genotype and phenotype, NGS results will help to discover / predict personalized therapy for DCIS patients.