Table 1.

Physical and circulating metabolic parameters of pregnancies at gestational day (GD) 19

Parameter	MC4R+/+	MC4R+/−
Lean mass (g)	255 ± 4	271 ± 4*
Visceral white adipose tissue (g)	14 ± 2	18 ± 2
Interscapular brown fat (g)	0.7 ± 0.1	0.8 ± 0.1
Tibia length (cm)	3.37 ± 0.02	3.43 ± 0.03
Number of fetuses	12 ± 1	12 ± 1
Reabsorbed fetuses	0 ± 0	0.5 ± 0.2*
Heart (g)	0.80 ± 0.05	0.90 ± 0.04
Kidneys (g)	1.58 ± 0.04	1.80 ± 0.03*
Adrenals (g)	0.06 ± 0.01	0.08 ± 0.02
Spleen (g)	0.53 ± 0.03	0.54 ± 0.04
Total cholesterol (mg/dL)	199 ± 24	298 ± 32*
Triglycerides (mg/dL)	475 ± 81	442 ± 70
Free fatty acids (μmol/L)	7250 ± 2420	9205 ± 2624
Glucose (mg/dL)	208 ± 9	242 ± 29
Insulin (ng/mL)	0.60 ± 0.07	0.64 ± 0.06
Leptin (ng/mL)	3.38 ± 0.63	5.03 ± 1.07
Adiponectin (ng/mL)	11.94 ± 1.53	9.57 ± 0.51

^*P < 0.05 versus MC4R+/+ pregnant rats.