Table 1. Pharmacokinetic Parameters Following Either Intravenous Bolus (IV) or Intraperitoneal (IP) Injection of BrA (1) in Mice (n = 3; mean ± SD).
parameter | units | IV | IP |
---|---|---|---|
dose | mg/kg | 23 | 23 |
Kel | h–1 | 0.93 ± 0.13 | |
Kab | h–1 | 0.24 ± 0.03 | |
t1/2 | h | 0.75 ± 0.11 | |
Cmax | μg/mL | 5.8 ± 3.9 | |
Tmax | h | 1.5 | |
AUC | μg·h/mL | 26 ± 5 | 20 |
Cp0 | μg/mL | 24 ± 6 | |
Vd | L/kg | 0.95 ± 0.27 | |
CL | mL/min/kg | 16 ± 3 |