Table 4.
Distribution of the H and R alleles of FcγRIIA and NA1 and NA2 alleles of FcγRIIIB in sickle cell disease patients.
| Group | Number of cases | FcγRIIA | FcγRIIIB | ||||
|---|---|---|---|---|---|---|---|
| H/H Number (%) |
H/R Number (%) |
R/R Number (%) |
NA1/NA1 Number (%) |
NA1/NA2 Number (%) |
NA2/NA2 Number (%) |
||
| SCD-mild | 110 | 20 (18.2) | 36 (32.7) | 54 (49.1) | 2 (1.8) | 55 (50) | 53 (48.2) |
| SCD-severe | 75 | 23 (30.7) | 25 (33.3) | 27 (36) | 0 (0) | 48 (64) | 27 (36) |
| SCD-total | 185 | 43 (23.3) | 61 (32.9) | 81 (43.8) | 2 (1.1) | 103 (55.7) | 80 (43.2) |
| Normals | 175 | 28 (16) | 82 (46.9) | 65 (37.1) | 22 (12.6) | 90 (51.4) | 63 (36) |
| *P value SCD Total versus normals | 0.085 | 0.0074 | 0.2 | 0.0006 | 0.4194 | 0.1608 | |
| *P value SCD Mild versus Normals | 0.632 | 0.019 | 0.0471 | 0.006 | 0.8143 | 0.0064 | |
| *P value SCD Severe versus Normals |
0.0172 | 0.0489 | 0.8637 | 0.03 | 0.0682 | 1.000 | |
*Chi-square test analysis comparing the FcγRIIA and FcγRIIIB gene frequencies in various groups.