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. 2013 Aug 22;1(3):e00063. doi: 10.1002/phy2.63

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Elastin content in the tissue was measured in 5-μm-thick sections with Van Gieson's stain (A–D). Images A–D represent interlobular arteries in the renal cortex. Hypertensive Dahl/SS rats show increased wall thickness, elastin disruption, and narrowing of lumen diameter (blue arrow). Bar diagram (E) shows mean wall thickness–lumen diameter ratio ± SEM from five individual experiments. *P < 0.05 versus Dahl/SS + Vehicle; ^†P < 0.05 versus Lewis (Vehicle and GM6001). Image magnification ×60.