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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Nature. 2013 Sep 11;502(7471):389–392. doi: 10.1038/nature12584

Figure 2. BIR-induced mutations.

Figure 2

a, The sequencing of the separated donor and recipient chromosomes of heterozygous Lys+ mutants. b, The effect of pif1Δ on BIR-induced frameshifts. Medians of mutation rates are shown. The arrows represent a reduction as compared to wt. c, The assay to study BIR-induced base substitutions in ura3–29 reporter. d, Depending on orientation, the selectable position of ura3–29 leading strand includes cytosine (C) or guanine (G). e, MMS amplifies BIR-induced base substitutions in orientation-dependent way. The arrows indicate an increase as compared to no-MMS control. See Extended Data Tables 1 and 2 for the details of statistical analysis and for the ranges of medians shown in e and b.