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Summary of differential pathophysiology
| Ticlopidine | Clopidogrel | Prasugrel | |
|---|---|---|---|
| Time to onset | 2–12 weeks | 0–2 weeks | Not measured |
| ADAMTS-13 levels | < 5% | Normal | Not measured |
| Antibodies, ADAMTS-13 | 100% | None | Not measured |
| Treatment | Emergency TPE | TPE done, but not clear if helpful | Not measured |
| Response to TPE | 90% | 50% | Not measured |
| Relapse | 0% | 0% | Not measured |
Abbreviations: ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1motif,member 13; TPE, therapeutic plasma exchange.
