Table 3. Characteristics of all ADNI aMCI subjects by biomarker group.
| Characteristic | Biomarker Negative (N = 9) |
Amyloid Only (N = 7) |
Amyloid + Neurodegeneration (N = 32) |
Neurodegeneration Only (N = 10) |
P |
|---|---|---|---|---|---|
| Age, years, median (IQR) | 72 (64, 77) | 75 (74, 80) | 75 (71, 81) | 77 (73, 83) | 0.45 |
| Male gender, no. (%) | 6 (67) | 5 (71) | 19 (59) | 7 (70) | 0.89 |
| Education, years, median (IQR) | 18 (16, 18) | 16 (14, 16) | 16 (14, 18) | 16 (16, 18) | 0.61 |
| APOE ε4 positive, no. (%) | 1 (11) | 6 (86) | 21 (66) | 4 (40) | 0.007 |
| MMSE, median (IQR) | 28 (27, 29) | 28 (28, 30) | 27 (26, 28) | 28 (26, 29) | 0.07 |
| CDR sum of boxes, median (IQR) | 1.5 (1.0, 2.0) | 1.0 (1.0, 1.5) | 2.0 (1.4, 2.6) | 1.0 (0.6, 1.9) | 0.23 |
| PIB Ratio, median (IQR) | 1.32 (1.24, 1.39) | 1.78 (1.67, 2.29) | 2.24 (2.09, 2.34) | 1.30 (1.28, 1.36) | -- |
| FDG Ratio, median (IQR) | 1.43 (1.36, 1.60) | 1.41 (1.39, 1.45) | 1.23 (1.16, 1.29) | 1.16 (1.05, 1.26) | -- |
| Adjusted Hippocampal Volume, median (IQR) |
0.56 (0.13, 1.29) | 0.03 (−0.29, 0.70) | −0.96 (−1.59, −0.71) | −0.85 (−1.63, 0.02) | -- |
| Diagnosis at follow-up, no. (%) | 0.19 | ||||
| CN | 0 (0) | 1 (17) | 2 (8) | 0 (0) | |
| MCI | 8 (89) | 5 (83) | 13 (50) | 6 (75) | |
| Dementia | 1 (11) | 0 (0) | 11 (42) | 2 (25) | |
| Annual change in MMSE | |||||
| N | 9 | 6 | 25 | 8 | |
| Median (IQR) | 0.00 (0.00, 1.05) | 0.43 (−1.44, 0.96) | −1.00 (−3.00, 0.00) | −2.41 (−3.19, 0.24) | 0.44 |
| Annual change in CDR-SB | |||||
| N | 9 | 6 | 25 | 8 | |
| Median (IQR) | 0.50 (0.00, 0.52) | −0.49 (−0.77, 0.25) | 0.50 (0.40, 1.45) | 0.49 (−0.12, 0.68) | 0.17 |