Table 4. Characteristics of all MCSA MCI subjects by amnestic and non-amnestic MCI.
| Characteristic | aMCI (N = 126) |
naMCI (N = 28) |
P |
|---|---|---|---|
| Age, years, median (IQR) | 82 (78, 86) | 84 (78, 87) | 0.66 |
| Male gender, no. (%) | 84 (67) | 19 (68) | 0.90 |
| Education, years, median (IQR) | 13 (12, 16) | 12 (12, 14) | 0.13 |
| APOE ε4 positive, no. (%) | 49 (40) | 6 (22) | 0.09 |
| MMSE, median (IQR) | 26 (24, 27) | 26 (24, 27) | 0.30 |
| CDR sum of boxes, median (IQR) | 1.0 (0.5, 1.5) | 0.8 (0.0, 1.5) | 0.61 |
| PIB Ratio, median (IQR) | 1.66 (1.36, 2.22) | 1.36 (1.32, 1.82) | 0.048 |
| PIB > 1.50, no. (%) | 72 (57) | 11 (39) | 0.09 |
| FDG Ratio, median (IQR) | 1.29 (1.18, 1.42) | 1.29 (1.19, 1.36) | 0.72 |
| FDG < 1.31, no. (%) | 68 (54) | 15 (54) | 0.97 |
| Adjusted Hippocampal Volume, median (IQR) |
−0.71 (−1.29, −0.29) | −0.22 (−0.60, 0.18) | <0.001 |
| HVa < 0.70, no. (%) | 64 (51) | 7 (25) | 0.013 |
| Biomarker Group | 0.28 | ||
| All biomarkers negative | 18 (14) | 7 (25) | |
| Amyloid positive only | 18 (14) | 4 (14) | |
| Amyloid positive & neurodegeneration |
54 (43) | 7 (25) | |
| Neurodegeneration only | 36 (29) | 10 (36) | |
| Diagnosis at follow-up, no. (%) | 0.79 | ||
| CN | 25 (26) | 6 (27) | |
| MCI | 57 (59) | 14 (64) | |
| Dementia | 14(15) | 2(9) | |
| Annual change in MMSE | |||
| N | 93 | 22 | |
| Median (IQR) | 0.00 (−1.58, 0.74) | −0.38 (−1.94, 0.00) | 0.46 |
| Annual change in CDR-SB | |||
| N | 96 | 22 | |
| Median (IQR) | 0.38 (0.00, 1.23) | 0.00 (−1.01, 0.40) | 0.016 |