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. 2013 Oct 21;8(10):e76451. doi: 10.1371/journal.pone.0076451

Figure 4. Tolerance induction of Col(I) does not confer protection against bleomycin-induced fibrosis.

Figure 4

(A) Schematic illustration of the experimental design. (B) Circulating antibodies specific to col(I) were unchanged in 21 day post bleomycin injury mice. Values represent mean ± SEM; number of animals: PBS = 4, BLEO = 4 and BLEO+col(I) Neb = 4. (C) At day 21 post bleomycin injury, lung tissue sections were stained for H&E and Masson's blue trichrome staining. Extensive collagen deposition was observed with bleomycin injury and col(I) nebulized lungs. Original magnifications: 10×. (Figure S2B: 1×).