Table 2.
Allele frequencies of seven SNPs in IGF1
| SNPs | Chr | Position (build 37.1) | Gene location | Alleles (1 >.2) | Risk allele | Risk allele frequency, %
|
P | Pc | OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n=446) | Controls (n=481) | |||||||||
| rs6214 | 12 | 102,793,569 | 3′-UTr | A >G | G | 35.9 | 33.8 | 0.35 | 1.10 (0.91–1.33) | |
| rs11111262 | 12 | 102,798,177 | Intron 3 | G >A | G | 80.8 | 80.6 | 0.88 | 1.02 (0.81–1.28) | |
| rs972936 | 12 | 102,824,921 | Intron 2 | A >G | A | 54.3 | 50.5 | 0.11 | 1.16 (0.97–1.39) | |
| rs5742629 | 12 | 102,857,263 | Intron 2 | A >G | A | 60.3 | 55.8 | 0.0502 | 0.21 | 1.20 (1.00–1.45) |
| rs12423791 | 12 | 102,858,828 | Intron 2 | G >C | G | 73.4 | 69.5 | 0.064 | 0.29 | 1.21 (0.99–1.48) |
| rs2162679 | 12 | 102,871,259 | Intron 1 | A >G | A | 68.4 | 66.3 | 0.34 | 1.10 (0.90–1.33) | |
| rs5742612 | 12 | 102,874,864 | 5′-UTR | T >C | T | 69.7 | 67.6 | 0.32 | 1.11 (0.91–1.35) | |
Note: P-values less than 0.1 were corrected for multiple hypothesis testing (Pc) by Haploview using 10,000 permutations.
Abbreviations: SNPs, single-nucleotide polymorphisms; IGF1, insulin-like growth factor 1 gene; Chr, chromosome; n, number; Pc, corrected P-value; OR, odds ratio; Cl, confidence interval; UTR, untranslated region.