Table 3. Fasting plasma glucose, insulin and QUICKI levels.
Group | N-V (n=6) | N-Ali (n=7) | MCD-V (n=7) | MCD-Ali (n=7) |
---|---|---|---|---|
Glucose (mg/dl) | 180.0±6.7 | 181.4±11.6 | 80.0±12.1 ## | 33.6±11.5 ##, * |
Insulin (ng/ml) | 0.53±0.07 | 0.44±0.03 | 0.31±0.04 ## | 0.25±0.01 ## |
QUICKI | 0.52±0.02 | 0.53±0.01 | 0.80±0.09 ## | 1.61±0.29 ##, * |
All data are expressed as the mean ± SEM. QUICKI: quantitative insulin sensitivity check index, a measurement of insulin sensitivity derived from the formula 1/ (log insulin ╳ glucose), MCD: methionine choline-deficient, N-V/N-Ali: normal (N) mice receiving vehicle (V) or aliskiren, MCD-V/MCD-Ali: MCD mice treated with vehicle or aliskiren. ## P<0.01 vs. N-V; * P<0.05 vs. MCD-V.