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. 2013 Oct 21;8(10):e77692. doi: 10.1371/journal.pone.0077692

Figure 3. The expression of chemokine CCL5 is up-regulated in co-cultures of BMMSCs cells and OTSCC.

Figure 3

Co-culture of OTSCC cells with BMMSCs results in the high expression of chemokine CCL5 in HSC-3 and SAS cells, but not in dysplastic DOK cells (A). Function-blocking monoclonal antibody against CCL5 (Mab CCL5) slightly inhibits BMMSC enhanced invasion area, but has no effect on the invasion depth, whereas the antibody against CXCL1 does not increase the inhibitory effect in OTSCC invasion (B, C).