Figure 7.

Dual therapy with imatinib and lapatinib stabilizes lung gas exchange in BLM-challenged mice. Time-dependent fluctuation of oxygen saturation (SpO₂) levels (determined on room air) in mice challenged with BLM (or saline) for 28 d and treated with imatinib and/or lapatinib (both at 50 mg/kg/d) beginning 15 d after initial BLM insult. Errors bars = sem (n=6). While administration of individual drugs resulted in partial recovery, a dual treatment yielded a cooperative effect on lung physiology, as indicated by the respective increases in dissolved oxygen levels.