Figure 5.

Exosites in the MMP-13 Cat domain defined by peptide binding. A) N-terminal region of peptide w, a representative A type (orange sticks with hydrophobic residues in cyan). Interacting residues on the Cat domain are represented by van der Waals spheres. B) Peptide b, a representative B-type peptide. Color scheme as in A. C) Exosites in MMP-13. The main exosites (dark gray) are the extended entrance to the active site. In the active site, the S₄–S₃′ subsites are each labeled.