Table 4.

Diagnostic effectiveness of p16 ^INK4a/Ki-67 immunocytostaining, L1 capsid protein immunocytostaining, and PANArray™ HPV chip test to predict follow-up CIN2+.

	Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)
p16 INK4a /Ki-67	76.2	51.4	48.5	78.3
L1 capsid protein	95.2	34.3	46.5	92.3
HR- HPV	66.7	67.7	54.5	77.8
16,18-HPV	38.9	87.1	63.6	71.1
p16 /Ki-67 + L1	61.9	68.6	54.2	75.0
p16 /Ki-67 + L1 + HR-HPV	100	53.1	55.9	100

PPV = positive predictive value. NPV = negative predictive value.

HR-HPV = positive for high risk HPV.

16,18-HPV =positive for HPV type 16 or HPV type 18.

p16/Ki-67 + L1 = positive for p16 ^INK4a/Ki-67 and negative for L1 capsid protein.

p16/Ki-67 + L1 + HR-HPV = (positive for p16 ^INK4a/Ki-67 and negative for L1 capsid protein) or (positive for high risk HPV).