Table 5.

Correlation coefficients, %ME, %MAE and Δ%MAE between AUC_0-9 and absolute dose or adjusted dose by age or anthropometric parameters

Independent variables	Correlation coefficient	ME (%)	MAE (%)	∆MAE (%)†	[95% C.I.]††
Dose	0.3963	8.32	21.64	1.36	[-1.11:3.83]
Dose/Age	0.2478	10.42	24.82	-1.82	[-4.50:0.85]
Dose/HT	0.4643	7.61	20.57	2.43	[-0.89:5.74]
Dose/TBW	0.3192	9.42	23.00	N.D.	N.D.
Dose/BMI	0.2531	9.86	23.75	-0.75	[-1.86:0.35]
Dose/BSA	0.4280	7.99	20.99	2.00	[-0.55:4.55]
Dose/IBW	0.5181	7.27	19.57	3.43	[-0.07:6.92]
Dose/LBW	0.3941	8.60	21.58	1.29	[-0.05:2.62]
Dose/FFM	0.4655	7.84	20.58	2.42	[-0.20:5.03]

HT, height; TBW, total body weight; BMI, body mass index; BSA, body surface area; IBW, ideal body weight; LBW, lean body weight; FFM, fat free mass.

ME, mean prediction error.

MAE, mean absolute prediction error.

N.D., not determined.

^†, ΔMAE = MAE(ƒ_(Dose/TBW)) - MAE(ƒ_{(Dose/parameter)}).

^††, 95% C.I., 95% confidential interval of ΔMAE.