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Gram-scale substrate scope of Mannich reaction.a
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Yields based on purified products. Diastereomeric ratios (dr) and enantiomeric excesses (ee) were determined by HPLC.
Yield determined by 1H NMR versus Bn2O as a standard; product characterized after hydrolysis of the benzophenone imine.
Reaction performed at a concentration of 0.07 M.
20 mol% catalyst was used; 0.9 mmol scale.
