Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| FKBP mutants | kcat (min−1) | Km (μM) | kcat/Km (M−1s−1) × 103 | Fold Relative Catalytic Efficiency Increase |
|---|---|---|---|---|
| FKBP38 | 65 ± 4.8 | 194 ± 16.5 | 5.6 | 1 |
| FKBP38/CaM/Ca2+ | 56 ± 2.4 | 120 ± 5.1 | 7.8 | 1.6 |
| NTD | 67 ± 0.9 | 224 ± 12.7 | 5.0 | 0.9 |
| NTD/CaM/Ca2+ | 39 ± 5.1 | 86 ± 6.4 | 7.7 | 1.4 |
| FKBD38 | 149 ± 10 | 192 ± 13.9 | 13.0 | 2.3 |
Abbreviations: FKBP38, FK506 binding protein 38; CaM/Ca2+, calcium-saturated calmodulin; NTD, N-terminal domain; FKBD38, FK506 binding domain of FKBP38.
