Table 1. Pharmacokinetics of DTG in BP, SF, RF, and RT following single and multiple doses.
Matrix | t1/2 (h) | Tmax (h) | Cmax (ng/mL, swab or g) | C24h (ng/mL, swab or g) | AUC0-24h (ng*h/mL, swab or g) | AUC0-inf (ng*h/mL, swab or g) | Matrix:BP AUC0-24h ratio | |
---|---|---|---|---|---|---|---|---|
BP | Single Dose | 12.2 (11.2-14.2) | 4 (2-5) | 2285 (1790-2743) | 704 (580-874) | 31335 (24948-39970) | 44902 (37253-58911) | - |
Multiple Doses | 14.1 (12.0-16.1) | 2.5 (1-3) | 2945 (2120-3400) | 954 (554-1093) | 41320 (28092-47219) | 60553 (37785-70036) | - | |
SF | Single Dose | 7.7 | 12 | 140 | 46.6 | 2018 | 2445 | 0.07 |
Multiple Doses | 11.5 (8.5-14.8) | 3.5 (3-6) | 244 (190-323) | 57.9 (47.6-94.0) | 3229 (2439-4376) | 4210 (3567-6377) | 0.07 (33) | |
RF | Single Dose | - | 24 | 17.0 | 17.0 | 91.9 | - | - |
Multiple Doses | - | 12 (6-12) | 26.5 (8.0-289) | 8.6 (0.9-88.9) | 300 (73.6-3160) | - | - | |
RT | Single Dose | 4.1 | 6 | 373 | 114 | 5281 | 5890 | 0.17 |
Multiple Doses | 8.4 | 4 | 418 | 139 | 7596 | 9617 | 0.17 |
Parameter estimates are presented as median (IQR) or point estimates for parameters generated from composite profiles. BP multiple dose estimates were calculated from concentrations following the last dose. Matrix:BP ratios are presented as the geometric mean AUC0-24h ratio (%CV) for SF after a single dose or geometric mean AUC0-24h ratio for RT and SF after multiple doses.