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Cytochrome P450 epoxygenase expression in tumor cell compartments and their potential role in cell–cell communication in the tumor stroma. Tumor cells, endothelial cells, and leukocytes express cytochrome P450 (CYP) enzymes which can convert arachidonic acid to epoxyeicosatrienoic acids (EETs, blue circles) or 20-hydroxyeicosatetraenoic (20-HETE), establishing an autocatalytic loop
