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. 2013 Oct 21;210(11):2371–2385. doi: 10.1084/jem.20122348

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© 2013 Zhou et al.

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Figure 3. — RhoA deficiency impairs multilineage hematopoiesis in a competitive transplantation experiment. (A–D) Lethally irradiated CD45.1⁺ recipient mice were reconstituted with equal numbers of CD45.2⁺ donor BM cells of the RhoA^fl/flMx-cre⁺ or Mx-cre⁻ genotype with CD45.1⁺ WT competitors. Three poly I:C injections were administrated into the recipients 8 wk after transplantation, and the chimerism of PB was analyzed monthly thereafter. 4 mo after poly I:C inductions, BM cells from the primary recipients were pooled and transplanted into secondary recipients. The kinetics of relative chimerism of donor-derived (CD45.2⁺) cells in total PB (A), myeloid (B), T (C), and B (D) cells in the peripheral circulation of recipients are shown. The x axes show units in months. Months 0–4: primary recipients; months 2–5: secondary recipients. Seven mice per genotype were examined. The results from a representative experiment of three independent experiments are shown. Error bars indicate SEM. *, P < 0.001.