Table 4.
Prevalence ratios for aTRH associated with study covariates among REGARDS study participants with CKD
| Characteristic | Age, Race, and Sex Adjusted | Multivariable Adjusteda |
|---|---|---|
| Age, per 10 yr | 0.99 (0.93 to 1.05) | 1.05 (0.98 to 1.13) |
| Women | 0.75 (0.67 to 0.84) | 0.87 (0.76 to 0.99) |
| Black race | 1.56 (1.38 to 1.75) | 1.49 (1.31 to 1.68) |
| Region | ||
| Nonbelt | 1 (ref) | 1 (ref) |
| Belt | 1.03 (0.91 to 1.17) | 1.04 (0.92 to 1.19) |
| Buckle | 1.04 (0.90 to 1.20) | 1.05 (0.91 to 1.22) |
| Income<$20,000 | 1.18 (1.04 to 1.33) | 1.08 (0.94 to 1.23) |
| Less than high school education | 1.07 (0.93 to 1.23) | 0.99 (0.85 to 1.15) |
| Waist circumference, per 15 cm | 1.19 (1.13 to 1.25) | 1.13 (1.07 to 1.20) |
| Diabetes | 1.44 (1.29 to 1.62) | 1.13 (1.00 to 1.28) |
| Current smoking | 0.98 (0.83 to 1.16) | 1.01 (0.85 to 1.20) |
| Alcohol use | 0.95 (0.83 to 1.07) | 1.02 (0.90 to 1.17) |
| Physical activity | ||
| None | 1 (ref) | 1 (ref) |
| 1–3 times/wk | 0.91 (0.80 to 1.04) | 1.00 (0.88 to 1.14) |
| 4+ times/wk | 0.79 (0.68 to 0.92) | 0.90 (0.77 to 1.05) |
| History of myocardial infarction | 1.34 (1.19 to 1.51) | 1.20 (1.06 to 1.36) |
| History of stroke | 1.23 (1.07 to 1.42) | 1.15 (1.00 to 1.33) |
| Statin use | 1.44 (1.29 to 1.62) | 1.29 (1.14 to 1.46) |
| Total cholesterol, per 40 mg/dl | 0.90 (0.84 to 0.95) | 0.97 (0.91 to 1.04) |
| HDL cholesterol, per 15 mg/dl | 0.86 (0.81 to 0.92) | 0.95 (0.88 to 1.02) |
| C-reactive protein>3 mg/L | 1.07 (0.96 to 1.20) | 0.96 (0.86 to 1.08) |
| eGFR, ml/min per 1.73 m2 | ||
| ≥60 | 1 (ref) | 1 (ref) |
| 45–59 | 0.95 (0.83 to 1.09) | 1.18 (1.00 to 1.40) |
| <45 | 1.25 (1.08 to 1.44) | 1.22 (1.05 to 1.43) |
| ACR, mg/g | ||
| <10 | 1 (ref) | 1 (ref) |
| 10–29 | 1.44 (1.16 to 1.79) | 1.32 (1.06 to 1.65) |
| 30–299 | 1.43 (1.20 to 1.70) | 1.50 (1.22 to 1.83) |
| ≥300 | 2.37 (1.97 to 2.85) | 2.24 (1.83 to 2.76) |
CKD was defined as an ACR≥30 mg/g or an eGFR<60 ml/min per 1.73 m2. Numbers are prevalence ratios (95% confidence intervals).
a
Adjusted for age, race, sex, geographic region, income, education, physical activity, current smoking, alcohol use, waist circumference, diabetes, total cholesterol, HDL cholesterol, statin use, C-reactive protein, history of myocardial infarction, history of stroke, ACR, and eGFR.