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. 2013 Oct 22;7:169. doi: 10.3389/fncir.2013.00169

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Copyright © Krenz, Hooper, Parker, Prinz and Baro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The LP I_A:I_h ratio is maintained in 5 μM DA when DA application is accompanied by DA-induced changes in slow wave activity. (A) A plot of the fold-changes in the LP I_A:I_hratio (mean ± SEM) throughout a 1 h superfusion with 5 μM DA and implementation of a recurring voltage step that mimicked the DA-induced 30% decrease in LP burst duration, but no change in cycle frequency. The ratio significantly decreased with time; repeated measures ANOVA with Dunnett’s post hoc tests that compare all time points to t = 0, F(3,4) = 7.322, p = 0.0032. (B) Plots of the fold-changes in peak LP I_A and I_h (mean ± SEM) from the same experiments as in (A). Repeated measures ANOVAs with Dunnett’s post hoc tests that compare all time points to t = 0 indicate that only LP I_A was significantly decreased [LP I_A: F(3,4) = 19.66, p < 0.0001; LP I_h, F(3,4) = 1.218, p = 0.3456]. *p < 0.05. (C) Plot of the fold-changes in the LP I_A:I_hratio (mean ± SEM) throughout a 1 h superfusion with 5 μM DA and implementation of a recurring voltage step that mimicked the DA-induced 30% decrease in LP burst duration and a 10% increase in cycle frequency. The ratio did not change significantly over time (repeated measures ANOVA, see text). (D) Plots of the fold-changes in peak LP I_A and I_h (mean ± SEM) from the same experiments as in (C) show that both currents are stably altered by 10 min; a and b indicate a significant change in LP I_A and I_h, respectively, based on repeated measures ANOVA with Dunnett’s post hoc tests that compare all time points to t = 0, p < 0.05 (see text).