Table 1.
Telomere and telomerase components in humans, S. cerevisiae, and S. pombe
| Human | Fission yeast | Budding yeast | Function |
|---|---|---|---|
| Telomeric proteins | |||
| TRF1 | Taz1 | NA | Bind dsDNA |
| TRF2 | Taz1 | NA | Bind dsDNA |
| Rap1 | Rap1 | Rap1 | Fission yeast protein binds dsDNA |
| TIN2 | Poz1 | NA | Bridge telomeric proteins via protein-protein interactions |
| POT1 | Pot1 | NA | Bind ssDNA |
| TPP1 | Tpz1 | NA | Enhance ssDNA binding of POT1; telomerase recruitment (for human TPP1) |
| NA | Ccq1 | NA | Telomerase recruitment |
| CTC1 | NA | NA | Part of a telomeric RPA-like complex |
| STN1 | Stn1 | Stn1 | Part of a telomeric RPA-like complex |
| TEN1 | Ten1 | Ten1 | Part of a telomeric RPA-like complex |
| NA | NA | Cdc13 | Binds ssDNA; part of a telomeric RPA-like complex |
| Telomere-associated proteins or complexes | |||
| Ku70-Ku80 | Ku70-Ku80 | Ku70-Ku80 | Contributes to telomeric heterochromatin |
| XPF-ERCC1 | NA | NA | 3′ overhang processing |
| EXO1 | NA | Exo1 | 5′ end resection |
| Apollo | NA | NA | 5′ end resection |
| MRE11 complex | NA | NA | TRF2 binding |
| RAD51D [Au: is the D meant to be there?] | NA | NA | Telomere protection against attrition and fusion |
| Tankyrase | NA | NA | PARsylation of TRF1 and resolution of sister telomere cohesion prior to mitosis |
| ORC | -NA | NA | Prevention of telomere circles |
| 9-1-1 complex | NA | NA | Telomere maintenance |
| RecQ helicases | NA | NA | TRF2 binding |
| HP1 | NA | NA | Sister telomere cohesion |
| Telomerase core components | |||
| TERT | Trt1 | Est2 | Telomerase reverse transcriptase protein component |
| TR | Ter1 | Tlc1 | Telomerase RNA component |
| Telomerase accessory factors | |||
| Dyskerin | NA | NA | Binds and stabilizes TR |
| EST1 | Est1 | Est1 | Telomerase recruitment (for) |
| NA | NA | Est3 | Associates with Est2; is essential in vivo |
| NA | NA | Ku70-80 | Nuclear localization of telomerase |
| NA | Sm, Lsm | Sm | Telomerase biogenesis, nuclear localization |
| TCAB1 | NA | NA | Localizes telomerase in Cajal bodies |
| Reptin | NA | NA | Associates with TERT in a cell cycle-dependent manner |
| Pontin | NA | NA | Associates with TERT in a cell cycle-dependent manner |
| PINX1 | NA | NA | Inhibitor of telomerase |
| HSP90 | NA | Hsp82 | Associates with telomerase |
| p23 | NA | Sba1 | Associates with telomerase |