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Schematic of RH family and domain architecture in P. falciparum. PfRH5 is a compact single domain which may represent the characteristic fold of the larger multidomain RHs. Cross-hatch stripes indicate the N-terminal portion of PfRH2a/b, which are homologous to PfRH5. Horizontal stripes indicate the N-terminal portion of PfRH1 and 4 with a lower level of sequence conservation. PfRH5 lacks a transmembrane domain and is refractory to gene deletion.
