Table 1.
CD4+/CD8+ T-Cell Ratios and Percentage Expression of CXCR3 and CCR5 on CD4+ and CD8+ T Cells Before and After Intensive Antifungal Therapy in Blood and CSF Samplesa
| Blood |
CSF |
|||||
|---|---|---|---|---|---|---|
| Start of Therapy | End of Therapy | P Value | Start of Therapy | End of Therapy | P Value | |
| CD4+/CD8+ T-cell ratio | 0.31 (0.06–0.62) | 0.28 (0.09–0.72) | NS | 0.13 (0.06–0.21) | 0.05 (0.02–0.12) | .001 |
| Proportion of CD4+ T cells, % | ||||||
| CXCR3+CCR5− | 12.6 (7.2–24.9) | 12.5 (4.5–20.2) | NS | 12.3 (3.3–21.3) | 20.5 (9.0–34.3) | <.0001 |
| CXCR3+CCR5+ | 6.1 (2.3–14.1) | 4.2 (1.7–46.3) | .002 | 18.5 (7.5–39.2) | 39.0 (23.6–100.0) | <.0001 |
| CXCR3-CCR5+ | 15.4 (5.4–28.9) | 14.5 (4.1–29.6) | NS | 22.9 (12.0–36.8) | 11.5 (4.4–21.4) | <.0001 |
| Proportion of CD8+ T cells, % | ||||||
| CXCR3+CCR5− | 11.0 (5.1–17.0) | 9.9 (6.1–16.2) | NS | 3.2 (1.8–5.9) | 4.3 (2.0–7.9) | NS |
| CXCR3+CCR5+ | 16.6 (10.3–31.7) | 18.6 (11.4–28.0) | NS | 43.1 (26.6–56.9) | 74.7 (62.0–85.1) | <.0001 |
| CXCR3−CCR5+ | 23.3 (12.2–35.9) | 27.4 (17.8–37.5) | NS | 40.0 (30.0–52.8) | 14.9 (7.0–25.0) | <.0001 |
Abbreviations: CSF, cerebrospinal fluid; NS, not significant.
a Values represent medians (interquartile ranges).