Table 2.
Correlation of 3 Markers of Tuberculosis Bacillary Burden With Interferon γ Responses to the Mycobacterial Antigens ESAT-6, WCL, and Ag85 Among 58 Adults With Culture-Confirmed HIV-Associated Tuberculosis in a Phase III Tuberculosis Vaccine Trial
| Mean Sputum Smear Grade |
Sputum Culture Grade |
Days to Sputum Culture Positivity |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ESAT-6 (n = 55) |
WCL (n = 56) |
Ag85 (n = 56) |
ESAT-6 (n = 57) |
WCL (n = 58) |
Ag85 (n = 58) |
ESAT-6 (N = 55) |
WCL (n = 56) |
Ag85 (n = 56) |
||||||||||
| Spearman Rank Correlation Coefficient |
Cuzick Test for Trend |
Spearman Rank Correlation Coefficient |
||||||||||||||||
| Subjects by Stratified Analyses | ρ | P Value | ρ | P Value | ρ | P Value | z | P Value | z | P Value | z | P Value | ρ | P Value | ρ | P Value | ρ | P Value |
| All subjects | −0.336 | .01 | −0.156 | .25 | 0.033 | .81 | −2.49 | .013 | −1.13 | .26 | −0.38 | .70 | 0.255 | .06 | 0.263 | .047 | 0.173 | .20 |
| Baseline CD4 T-cell count, cells/µL | ||||||||||||||||||
| <350 | −0.283 | .14 | −0.035 | .86 | 0.049 | .81 | −0.64 | .52 | 0.37 | .71 | 0.83 | .41 | 0.199 | .30 | 0.189 | .32 | 0.065 | .74 |
| ≥350 | −0.285 | .15 | −0.111 | .58 | 0.023 | .91 | −2.25 | .02 | −1.69 | .09 | −1.26 | .21 | 0.289 | .14 | 0.393 | .04 | 0.262 | .17 |
| Vaccine receipt | ||||||||||||||||||
| SRL 172 vaccine | −0.625 | .001 | −0.457 | .03 | −0.219 | .30 | −3.19 | .001 | −2.32 | .02 | −1.67 | .10 | 0.517 | .008 | 0.445 | .03 | 0.328 | .11 |
| Placebo | −0.050 | .79 | 0.043 | .81 | 0.122 | .51 | 0.00 | >.99 | 0.41 | .68 | 0.36 | .72 | 0.129 | .48 | 0.181 | .31 | 0.078 | .67 |
| Prior active tuberculosis | ||||||||||||||||||
| Yes | 0.205 | .63 | 0.675 | .07 | 0.321 | .44 | 1.03 | .30 | 1.42 | .16 | 0.52 | .60 | 0.359 | .38 | 0.755 | .03 | 0.769 | .03 |
| No | −0.503 | <.001 | −0.348 | .02 | −0.083 | .58 | −3.07 | .002 | −1.98 | .048 | −0.79 | .43 | 0.255 | .08 | 0.210 | .14 | 0.088 | .54 |
| TST reaction, mm | ||||||||||||||||||
| <5 | −0.244 | .24 | −0.121 | .57 | −0.108 | .62 | −2.25 | .02 | −1.56 | .12 | −1.24 | .21 | 0.126 | .56 | −0.019 | .93 | −0.088 | .67 |
| ≥5 | −0.432 | .02 | −0.199 | .29 | 0.253 | .18 | −1.53 | .13 | −0.13 | .90 | 1.23 | .22 | 0.171 | .36 | 0.250 | .18 | 0.003 | .98 |
| Isoniazid receipt | ||||||||||||||||||
| No | −0.209 | .25 | 0.011 | .95 | −0.012 | .95 | −1.54 | .12 | −0.36 | .72 | −0.82 | .41 | 0.292 | .10 | 0.187 | .29 | 0.223 | .20 |
| Yes | −0.535 | .009 | −0.414 | .049 | 0.136 | .54 | −1.97 | .049 | −1.36 | .18 | 0.74 | .46 | 0.094 | .66 | 0.275 | .19 | 0.014 | .95 |
Abbreviations: Ag85, antigen 85; ESAT-6, early secreted antigenic target 6; TST, tuberculin skin test; WCL, whole-cell lysate; z, Cuzick z statistic.