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. Author manuscript; available in PMC: 2013 Oct 22.
Published in final edited form as: J Muscle Res Cell Motil. 2010 Aug 28;31(3):227–239. doi: 10.1007/s10974-010-9228-3

Fig. 3.

Fig. 3

Isoproterenol dose response curves in NTG and TG mouse hearts. Mouse hearts from β-TM TG (n = 5), γ-TM TG (n = 5), βγ-DTG (n = 5) and NTG controls (n = 6) at 4 months of age were subject to isolated heart analyses with increasing concentrations of isoproterenol (10−11–10−7 mol/l). Administration of the β-adrenergic agonist isoproterenol elicits a robust positive inotropic response in γ-TM TG, βγ-DTG and NTG controls but a partially attenuated response in β-TM TG hearts. a Plot of increasing concentrations of isoproterenol versus maximum rate of pressure development; b plot of increasing concentrations of isoproterenol versus maximum rate of pressure decline; c plot of increasing concentrations of isoproterenol versus time to peak pressure; d plot of increasing concentrations of isoproterenol versus half time to relaxation. “*” Indicates the entire β-TM curve is statistically different from NTG; “#” indicates NTG at this specific concentration is statistically different from γ-TM and βγ-DTG at P < 0.05