TABLE 4.
Patient | Age, years | Sex | Tanner stage |
GLP-2 levels, pmol/L
|
Sugar absorption, %
|
||||
---|---|---|---|---|---|---|---|---|---|
Fasting | Postprandial | 3-OMG | Lactulose | Mannitol | Ratio | ||||
1 | 8 | Female | 2 | 17 | 42 | 76.3 | 1.39 | 43.2 | 0.032 |
2 | 9 | Female | 2 | 18 | 28 | 56.8 | 0.71 | 40.6 | 0.017 |
3 | 6 | Male | 2 | 17 | 33 | 44.1 | 0.96 | 25.68 | 0.037 |
4 | 7 | Male | 2 | 16 | 26 | 48.2 | 1.23 | 36.06 | 0.034 |
5 | 8 | Female | 2 | 13 | 34 | 90.4 | 0.98 | 37.61 | 0.026 |
6 | 10 | Female | 2 | 14 | 23 | 56.6 | 0.85 | 27.58 | 0.030 |
7 | 8 | Male | 2 | 18 | 24 | 49.7 | 0.76 | 24.00 | 0.032 |
8 | 10 | Male | 3 | 14 | 21 | 53.7 | 0.64 | 36.91 | 0.017 |
9 | 7 | Female | 2 | 15 | 26 | 54.7 | 1.07 | 25.52 | 0.041 |
10 | 10 | Male | 3 | 20 | 38 | 61.3 | 1.05 | 31.22 | 0.033 |
Mean ± SD | 10.3±1.6 | 16.2±2.2 | 30.4±6.6 | 55.7±8.7 | 0.96±0.23 | 32.8±6.9 | 0.030±0.008 |
Glucagon-like peptide 2 (GLP-2) levels determined by radioimmunoassay using a specific antibody for intact GLP-2 (amino acid residues 1 to 33) (20). Sugar probe absorption is reported as the proportion of orally administered probe recovered in urine after an overnight collection, quantified using high-performance liquid chromatography (23,34). 3-OMG 3-O-methyl glucose